Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy

Molecular imaging of hypoxia.

A wide variety of imaging approaches have been developed in the past few decades for monitoring tumor oxygenation and hypoxia in vivo. In particular, nuclear medicine has seen the development of several radiolabeled hypoxia markers and is the preferred method for imaging of tumor hypoxia. Hypoxia imaging is increasingly being used in the clinical setting and is progressing from a mere detection...

Hypoxia and glioblastoma therapy

is the most common primary malignancy in adults. Despite improvements in chemoradiotherapeutic strategies, patients typically survive for less than one year [1]. Bevacizumab (BVZ), a humanized monoclonal antibody against vascular epithelial growth factor (vegf), alters the kinetics of ligand binding and has been shown to abrogate angiogenesis in different types of solid tumors [2]. The initial ...

Molecular Mechanisms Regulating Macrophage Response to Hypoxia

Monocytes and Macrophages (Mo/Mɸ) exhibit great plasticity, as they can shift between different modes of activation and, driven by their immediate microenvironment, perform divergent functions. These include, among others, patrolling their surroundings and maintaining homeostasis (resident Mo/Mɸ), combating invading pathogens and tumor cells (classically activated or M1 Mo/Mɸ), orchestrating wo...

Hypoxia helps glioma to fight therapy.

Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and anaplastic gliomas and 6 - 12 month for glioblastoma. Increasing malignancy of gliomas correlates with an increase in cellularity and a poorly ...

Molecular Mechanisms of Acclimatization to High Altitude Hypoxia: Role of Hypoxia Mimetic Cobalt Chloride